What is CBG and What Does it Do

what is cbg

CBG is the mother of all the cannabinoids from marijuana. You may be very familiar with THC and CBD. 

There are around 400 compounds that include terpene and cannabinoids in marijuana, and only a few are in the limelight. The ones that are discovered are beneficial to health. Like CBD, it is known for its therapeutic benefits for both body and mental conditions.

But what is CBG? Why is it the mother of all the cannabinoids that can be found in marijuana? This article will show you why.

What is CBG All About?

CBG or cannabigerol is among the hundred cannabinoids found in marijuana. Cannabinoid means a unique type of chemical compound, and it acts as a receptor in the human cell. It happens when the neurotransmitters in the brain are discharged.

There’s only a little amount of CBG in marijuana and hemp. Due to not being so abundant, it is categorized as a minor cannabinoid despite its function. You will find 1% of it in marijuana and below 2% in hemp.

Ralph Mechoulam and Yehiel Gaoni, who are Israeli scientists, discovered and isolated CBG in 1964. Then another discovery surfaced after some years by Japanese scientists. They figure out that CBG begins as CBGA, which is a cannabigerolic acid that is converted into an active cannabinoid when the heat is applied. 

More About CBG

CBG is a form of CBGA or cannabigerolic acid that doesn’t contain acid. It is called the mother of all cannabinoids as it has a structure that works as an institution for all those things. It can synthesize other cannabinoids. 

As the Cannabis plants mature, there’s an enzyme that transforms CBGA into other kinds of acid like THCA or tetrahydrocannabolic acid, CBDA or cannabidiolic acid, and CBCA or cannabichromenic acid. With the use of heat in the process called decarboxylation, these acidic substances are changed into the active form called THC, CBD, and CBC.

Genetic manipulation and cross-breeding were done by Cannabis breeders. Scientists discovered that a higher amount of CBG can be extracted from a budding plant. So CBG oil can be obtained within six to eight weeks of flowering. It is the stage that it’s at its highest quantity as it hasn’t converted yet into an active compound.

Does CBG Bring the Same High From THC?

CBG like CBD is a non-psychoactive compound. In terms of brain chemistry, it is an antagonist that can step in the trippy high caused by THC. It can prevent the creation of ultra-potent strain. Marijuana users may experience a buzzed or bad trip if there’s no CBG that neutralizes the cannabinoids. 

The Benefits of CBG Confirmed by Research

Humans depend on the health benefits of Cannabis for thousands of years. But it’s only in the last few decades that researchers and scientists tested and discovered them as they went over the compounds of weed.

Some parts are now clear on how cannabinoids react with the natural system of the body to strengthen the well-being. Other cannabinoids cast their shadow on CBG even though it carries the fundamental structure. 

Although the discovery of the exact benefits from CBG still needs further study, it is deemed to promote good health. It happens due to its connection with cannabinoid, 5-HT1A, vanilloid receptor system, and G-protein-coupled a2 adregenic. It boosts the function and efficiency of the body. 

How Beneficial is CBG?

CBG influences the body the same way as other cannabinoids. They interact with the endocannabinoid system in a person’s body. The endocannabinoid system is a signal network that maintains the balance among body functions.

When you use Cannabis, your body soaks up cannabinoids, including CBG. All of them have the same chemical for synthesizing endocannabinoids naturally. Then it interacts with the cannabinoid receptors.

CBG has the potential to increase the amount of Anandamine, which is a type of body’s endocannabinoid and ensures the efficiency of the said system. CBG can break down the enzymes of Anandamine, so there will be more of it. 

CBG is also connected with 5-HT1A receptors, so the neurotransmitter serotonin was released. Serotonin is related to the control of mood. 

It was found that it is also related to TrpV1 or vanilloid receptor 1. It is the receptor that detects and manages body sensations as well as environmental stimuli.

What is CBG Based on the Study and Research?

There are promising results of the study on CBG that would benefit the physiological system. Here are some of the discoveries.

1. CBG is linked with endocannabinoid receptors, which are commonly found in the eyes structure. It has shown that it can reduce intraocular pressure, so it makes an effective treatment for glaucoma. It proves itself as a powerful vasodilator with a neuroprotective effect.

2. An experiment done with CBG with the utilization of mice shows its ability to lessen inflammation of bowel movements.

3. It can also fight cancer as it acts as a block receptor against cancer cells. It subdues the colorectal cancer cells within the mice in a study. It implies that it can slow down colon cancer growth.

It can eliminate carcinogens in the colon. Therefore, it’s a magnificent sign that can be used for colon cancer treatment.

4. The research that was done in Europe resulted in that it is an efficient antibacterial agent. The topical formula of Cannabis is known to be effective in the battle of skin infections since the 1950s. But the chemical composition of the plant wasn’t clear at that time.

5. Researchers removed delta-9 THC as they had purified CBG. It was done in 2017 with the result of showing some potential for enhancing appetite.

It can be a therapy for people who are struggling with cachexia. It is a condition that serious cases of weight loss are experienced by cancer patients in the late stage. It may happen with other diseases too.

6. CBG was included in the five cannabinoids used in the study about bladder contractions. It shows its ability in curbing muscle contractions. It has chances for it to be used in the prevention of bladder dysfunction disorder.

Does CBG Have Side Effects?

There’s a lot of benefits that CBG can give. A therapeutic dose of this cannabinoid is helpful. Too much of everything can be bad, so it would be the same thing with CBG. 

There will be negative effects if it is taken more than 300 milligrams per kilogram of a human’s body weight. For example, a 180-kg person would only need to take 25 mg of CBG to counter any pain.

25 mg is equal to one-eighth of a teaspoon. It can be in the form of a tincture or an edible. So if you would go for a therapeutic dose, side effects will be absent.


It’s fine to try CBG for therapeutic benefits, and you’ve already known the important things about the mother of cannabinoids. This article has given you enough answers to the question, ‘what is CBG?’’.

There will be future studies and more confirmation regarding its health benefits. So stay tuned, especially if you’re a Cannabis lover.

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About The Author:

James Carico

James Carico

James is a passionate health and lifestyle blogger whose expertise is in the medical marijuana realm. His goal is to break the stigma towards marijuana and share knowledge and information about its brilliant characteristics that offer recreational benefits and boast medical benefits. He is an advocate of marijuana legalization worldwide as he believes everyone should have access to nature’s wonder herb. James enjoys a pot of Super Silver Haze marijuana in his free time as it not only brings him in a good mood but also relieves his body from pain and tension. He writes mainly on medical marijuana’s history, uses and benefits, and cultivation.